Bioreactor Selection and Scale-Up Training Course

Name: Advanced Bioreactor Selection, Scale-Up and Optimisation Training Course
Availability: InStock

Make defensible bioreactor choices and translate cell-culture or fermentation processes from development to production.

Bioreactor Selection and Scale-Up Training Course

At a glance

Duration: 1 Week
Format: Classroom
Cities: Toronto, Prague, Singapore, Muscat, Athens, Geneva and more
Next session: 1 – 5 November 2026, Toronto
Average fee: 7,500 €

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Advanced Bioreactor Selection, Scale-Up and Optimisation Training Course

Overview

Advanced Bioreactor Selection, Scale-Up and Optimisation Training Course is a one-week course for bioprocess engineers, scientists, manufacturing technologists, and technical leaders who leave with a Bioreactor Selection and Scale-Up Decision Portfolio. Participants connect reactor choice, cell requirements, mass transfer, mixing, heat removal, instrumentation, process control, scale translation, contamination prevention, and lifecycle economics. Agile Leaders Training Center presents bioreactor selection and scale-up as an integrated engineering discipline.

Who Should Attend

Bioprocess development functions responsible for cell culture, fermentation, and process characterization
Process engineering functions responsible for vessel selection, scale translation, and technology transfer
Manufacturing functions responsible for bioreactor operation, monitoring, deviation response, and productivity
Automation functions responsible for sensors, control loops, alarms, data, and process analytical technology
Quality functions responsible for process control, contamination risk, validation, and change management
Technical leadership functions responsible for capacity, investment, platform, and lifecycle decisions

The course assumes participants already work with biological processes or process engineering and leaves out introductory biology, equipment maintenance, and product-specific regulatory submissions.

Departments and Industries

The course supports departments and industries that develop, scale, operate, or govern biological production systems.

Biopharmaceutical and vaccine process-development departments
Industrial biotechnology and fermentation operations
Food, enzyme, and cultured-ingredient manufacturing
Cell and gene therapy manufacturing functions
Research, pilot-plant, and technology-transfer groups
Engineering, automation, quality, and capital-project teams

Learning Objectives

By the end of this course, participants will be able to:

Compare bioreactor configurations against biological and production requirements
Analyze mixing, oxygen transfer, heat removal, and shear constraints
Build monitoring and control strategies for critical process parameters
Evaluate scale-up and scale-down criteria across operating ranges
Diagnose performance, contamination, and control deviations
Prioritize equipment options using lifecycle and risk evidence

Course Agenda

Day 1: Selection Architecture and Process Requirements

Biological Process Requirement Definition Canvas
Stirred-Tank, Airlift, Rocking, and Fixed-Bed Comparison Matrix
Batch, Fed-Batch, Perfusion, and Continuous Mode Decision Tree
Single-Use and Stainless-System Selection Scorecard
Bioreactor Capacity and Lifecycle Cost Model

Day 2: Mixing, Transfer, and Cell Environment

Power-per-Volume and Impeller Tip-Speed Assessment
Mixing-Time and Concentration-Gradient Mapping Method
Oxygen Transfer Rate and kLa Calculation Sheet
Gas Flow, Carbon Dioxide Removal, and Foam Control Map
Heat-Transfer, Shear, and Cell-Sensitivity Operating Window

Day 3: Monitoring and Process Control

Critical Process Parameter and Quality Attribute Linkage Map
Sensor Selection, Calibration, and Data-Integrity Checklist
Dissolved-Oxygen Cascade Control Logic
Feed, pH, Temperature, and Antifoam Control Strategy
Process Analytical Technology Monitoring Plan

Day 4: Scale Translation and Reliable Operation

Scale-Up Criterion Selection Decision Matrix
Laboratory-to-Production Operating Range Translation
Scale-Down Model Design and Qualification Plan
Contamination Pathway and Aseptic Boundary Analysis
Deviation Diagnosis and Root-Cause Evidence Tree

Day 5: Bioreactor Decision Practice

Exercise: Select a Bioreactor for a Cell-Culture Case
Exercise: Balance Mixing, Oxygen, Shear, and Heat Constraints
Exercise: Design a Monitoring and Control Architecture
Exercise: Build a Scale-Up and Troubleshooting Plan
Capstone Exercise: Bioreactor Selection and Scale-Up Decision Portfolio

Practical Exercises

The course uses suggested activities drawn from biologics, fermentation, food biotechnology, and cell-based manufacturing.

Suggested activity: compare reactor platforms using biological needs, operating mode, contamination exposure, capacity, and lifecycle cost.
Suggested activity: calculate an oxygen-transfer requirement and test its compatibility with mixing, shear, gas flow, and heat constraints.
Suggested activity: map sensors, control loops, alarms, sampling, and response actions for a production scenario.
Suggested activity: integrate selection, operating ranges, scale criteria, risks, and troubleshooting evidence in the capstone portfolio.

FAQs

Who suits advanced bioreactor selection and scale-up training, and what does it assume?

Advanced bioreactor selection and scale-up training suits professionals who already handle biological processes, process engineering, manufacturing, automation, quality, or technical investment decisions.

How does bioreactor selection training differ from introductory biotechnology training?

Bioreactor selection training evaluates equipment, transport phenomena, controls, scale effects, risks, and economics, while introductory biotechnology training establishes basic biological concepts and laboratory methods.

Which criteria guide bioreactor selection for biotechnology processes?

Bioreactor selection uses cell sensitivity, oxygen and mixing demand, heat removal, operating mode, sterility, scale, control capability, facility fit, changeover needs, and lifecycle cost.

How is bioreactor scale-up evaluated without holding every parameter constant?

Bioreactor scale-up evaluates acceptable operating ranges for parameters such as power per volume, tip speed, mixing time, gas flow, oxygen transfer, shear, and heat removal against biological performance.

Why does process analytical technology matter in bioreactor control?

Process analytical technology supports timely measurement, process understanding, control decisions, trend detection, and evidence that critical conditions remain within the intended operating range.

Conclusion

The course integrates reactor selection, transport phenomena, cell requirements, control, scale translation, contamination prevention, troubleshooting, and economics. Participants take back a Bioreactor Selection and Scale-Up Decision Portfolio. The portfolio changes technical decisions by making requirements, assumptions, tradeoffs, operating ranges, controls, risks, and evidence explicit.

credits: 5 credit per day

Course Mode: full-time

Provider: Agile Leaders Training Center

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Showing 1-20 of 57 events

Location	Dates	Duration	Mode	Price
Toronto	Week 44, 2026 1 – 5 November 2026	1 Week	Onsite	€16,000
Prague	Week 45, 2026 2 – 6 November 2026	1 Week	Onsite	€7,500
Singapore	Week 46, 2026 9 – 13 November 2026	1 Week	Onsite	€6,500
Muscat	Week 46, 2026 15 – 19 November 2026	1 Week	Onsite	€6,500
Athens	Week 48, 2026 23 – 27 November 2026	1 Week	Onsite	€7,500
Geneva	Week 48, 2026 29 November – 3 December 2026	1 Week	Onsite	€8,000
Madrid	Week 50, 2026 7 – 11 December 2026	1 Week	Onsite	€6,500
Porto	Week 51, 2026 14 – 18 December 2026	1 Week	Onsite	€6,500
Nairobi	Week 51, 2026 20 – 24 December 2026	1 Week	Onsite	€6,000
Zanzibar	Week 52, 2026 27 – 31 December 2026	1 Week	Onsite	€6,000
Berlin	Week 01, 2027 4 – 8 January 2027	1 Week	Onsite	€6,500
Johannesburg	Week 01, 2027 10 – 14 January 2027	1 Week	Onsite	€6,000
Phuket	Week 02, 2027 17 – 21 January 2027	1 Week	Onsite	€8,000
Paris	Week 04, 2027 25 – 29 January 2027	1 Week	Onsite	€6,500
New York	Week 05, 2027 1 – 5 February 2027	1 Week	Onsite	€16,000
Abu Dhabi	Week 06, 2027 8 – 12 February 2027	1 Week	Onsite	€6,500
Bali	Week 06, 2027 14 – 18 February 2027	1 Week	Onsite	€6,500
Marbella	Week 07, 2027 21 – 25 February 2027	1 Week	Onsite	€6,500
Sharm El-Sheikh	Week 09, 2027 1 – 5 March 2027	1 Week	Onsite	€5,200
Montreux	Week 10, 2027 8 – 12 March 2027	1 Week	Onsite	€8,000

Frequently asked questions

What does this course cover?

OverviewAdvanced Bioreactor Selection, Scale-Up and Optimisation Training Course is a one-week course for bioprocess engineers, scientists, manufacturing technologists, and technical leaders who leave with a Bioreactor Selection and Scale-Up Decision Portfolio. Participants connect reactor choice, cell requirements, mass transfer, mixing, heat removal, in…

Are training dates available?

Yes. Available dates and destinations are listed in the course dates section on this page.

How can I register?

Choose an available date on this page and complete the registration form, or send a programme enquiry.

Can I download the course brochure?

Yes. Use the brochure download link provided on this page.

Bioreactor Selection and Scale-Up Training Course